Go to your game list, right-click the game, and select Remove -> Remove All Caches .
The "The PS3 application has likely crashed, you can close it" error in RPCS3 is a common frustration for emulation enthusiasts. This message is a generic catch-all indicating that the virtual PlayStation 3 environment has hit a critical instruction it cannot process. Go to your game list, right-click the game,
Usually means the emulator encountered an unimplemented function. In this case, you may simply have to wait for a future emulator update. To help you get back to gaming, let me know: Which game are you trying to play? What are your PC specs (CPU and GPU)? Does the crash happen at startup or during gameplay ? Go to your game list