Right-click the application and select "Run as Administrator" to give it the permissions it needs to manage memory.
While the idea of a "plug-and-play" professional layout tool is appealing, there are several hurdles to consider when using legacy portable software. QuarkXPress 7.0 Portable
For the first time, users could apply transparency effects directly within Quark without needing to round-trip to Photoshop. QuarkXPress 7.0 Portable
Non-destructive image editing directly on the layout. Why Users Seek a Portable Version QuarkXPress 7.0 Portable
QuarkXPress 7.0 Portable is incredibly lightweight compared to today’s Creative Cloud apps. It can run on older hardware or budget laptops that would otherwise lag under the weight of current professional design software. Technical Considerations and Risks